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  • Low-Laser Neuro-modulation (tPBM) Device
  • Low-Laser Neuro-modulation (tPBM) Device

Low-Laser Neuro-modulation (tPBM) Device


Among new neuromodulation approaches, transcranial photobiomodulation (tPBM) is characterized by the noninvasive delivery of low-level light, transcranially. Light penetrates the skin and the skull and then is absorbed into the brain tissue by specific chromophores, such as water, oxyhemoglobin (HbO2), deoxyhemoglobin (Hb), myoglobin, melanin, cytochromes, and flavin. The target for light within single neurons is the mitochondria, where tPBM stimulates cytochrome c oxidase. The consequence is that light enhances mitochondrial activity and hence ATP synthesis, leading to an activation of transcription factors associated with increased functional activity. Coherently, research has shown that tPBM boosts brain energy metabolism as well as cognition in preclinical and clinical studies.



Transcranial Photobiomodulation (tPBM) uses lasers or light-emitting diodes to apply red or near-infrared light to the brain, thereby improving the metabolic capacity of neurons and stimulating anti-inflammatory responses, antioxidants, neurogenesis, and synaptogenesis.


Unlike drug treatments, tPBM is noninvasive and has few side effects. tPBM improved cognitive rigidity, behavior, attention span, and sleep quality

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